Beilstein J. Nanotechnol.2014,5, 937–945, doi:10.3762/bjnano.5.107
delivery system for bone metastatic prostate cancer was developed, characterized, and evaluated in vitro. NDs were conjugated with the Asp–Gly–Glu–Ala (DGEA) peptide to target α2β1 integrins over-expressed in prostate cancers during metastasis. To facilitate drug delivery, DOX was adsorbed to the surface
from 2.5% to 12% cell death and 11% to 34% cell death, respectively. These studies confirmed that the delivery and efficacy of DOX were enhanced by ND-DGEA conjugates. Thus, the targeted ND-DGEA+DOX system provides a novel approach for decreasing toxicity and drug doses.
Keywords: DGEApeptide
prostate cancers, targeted drug delivery with a ligand that interacts with these integrins should allow for increased accumulation of drug systems in cancer cells versus normal cells or tissues. Asp–Gly–Glu–Ala (DGEA) peptide has been identified as a binding peptide for the α2β1 integrins; it corresponds
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Scheme 1:
Nanodiamond-DGEA peptide conjugation. The carbodiimide reaction used EDAC and sulfo NHS to form a s...